| 摘要 |
A compound of formula (I); a pharmaceutical composition comprising the compound; and the use of the compound in the preparation of a medicament for inhibiting cholesterol biosynthesis or lowering blood serum cholesterol levels and/or modulating blood serum cholesterol levels, lowering LDL cholesterol and/or increasing HDL cholesterol, or treating dyslipidemia, mixed dyslipidemia, LDL Pattern B, LSL Pattern A, hyperlipidemia, hypercholesterolemia, hypo á-lipoproteinemia, hyperlopoproteinemia or hypertriglyeridemia, and other aberrations of apolipoprotein B metabolism, or reducing levels of Lp(a), or treating or preventing other cholesterol-related disease, or treating or preventing or reversing progression of atherosclerosis, or preventing or treating Alzheimer's disease, osteoporosis and/or osteopenia, or reducing inflammatory markers, reducing C-reactive protein, or preventing or treating low grade vascular inflammation, stroke, dementia, coronary heart disease, primary and secondary prevention of myocardial infarction, or preventing or treating stable and unstable angina, or primary prevention of coronary events, or secondary prevention of cardiovascular events, or preventing or treating peripheral vascular disease or peripheral arterial disease, acute vascular syndromes, preventing or reducing the risk of undergoing myocardial revascularisation procedures or preventing or treating microvascular diseases such as nephropathy, neuropathy, retinopathy and nephritic syndrome, or preventing or treating hypertension, type I diabetes, type II diabetes and related diseases, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids or glycerol, obesity, LDL complications, dysmetabolic syndrome and related diseases, and sexual dysfunction, preventing and treating malignant lesions, premalignant lesions, gastrointestinal induced asthenia (fatigue), irritable bowel syndrome, Crohn's disease, gastric ulceritis and gallstones, HIV infection, drug-induced lipodystrophy and proliferative diseases, improving coagulation homeostasis, reducing PAI-1 activity, reducing fibrinogen, and/or reducing platelet aggregation and/or improving endothelial function.
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