| 摘要 |
PROBLEM TO BE SOLVED: To modify the rate of release of an encapsulated active compound from a multivesicular liposomal (MVL) formulation. SOLUTION: The rate of release of the encapsulated active compound from the multivesicular liposomal (MVL) formulation is modified by selection of a neutral lipid component. A family of MVL formulations containing different slow:fast release neutral lipid molar ratios displays different release rates depending upon the molar ratio of the fast release neutral lipid to the slow release neutral lipid in each member. Incubation in plasma or a plasma-like medium at in vivo temperatures so as to obtain a release rate curve for each member allows selection from among the members of the family of a liposomal formulation with a desired rate of release in vivo. COPYRIGHT: (C)2004,JPO&NCIPI
|
