New 1-chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro(5.5)undec-2-enes useful as antibiotics for treating infectious diseases and for preventing transmission of staphylococcal infections in cattle

摘要

1-Chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro[5.5]undec-2-enes (I) are new. 1-Chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro[5.5]undec-2-enes of formula (I) are new. [Image] R1>H, acetyl, benzoyl, Me, Et or glycosyl; R2>H, halo or NH2; R3>H or halo; R4>H, 1-10C alkyl, halo or NH2; and R5>H, alkyl or C-glycoside. An independent claim is also included for a (I)-containing extract of Laurencia seaweed. ACTIVITY : Antibiotic. The zone of inhibition produced by placing a 6 mm sensi-disc coated with 1-chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro[5.5]undec-2-ene on a methicillin-resistant Staphylococcus aureus culture and incubating at 37 [deg]C for 18-20 hours was 8.3 mm. MECHANISM OF ACTION : None given.