CHEMICAL DERIVATIVES BINDING VERY SPECIFICALLY WITH G-QUADRUPLEX DNA STRUCTURES AND USE THEREOF AS A SPECIFIC ANTI-CANCER AGENT

摘要

The invention relates to cancer therapy and concerns novel anti-cancer agents exhibiting a highly specific action mechanism. The invention also relates to novel chemical compounds and the therapeutic use thereof in man. The invention describes the preparation of heterocylic diamides of general formula (IB) as highly specific G quadruplex DNA ligands and the use thereof as telomerase inhibitors in man. (IB) nitrogenous aromatic cycle comprising a nitrogen atom in a quaternary form (NR3)p CO distributor (CO)m NR'3)qu X- aromatic or non-aromatic cycle.