COMPOSITIONS AND METHODS FOR TARGETED BIOLOGICAL DELIVERY OF MOLECULAR CARRIERS

摘要

The present invention relates generally to compositions adapted to provide delivery of therapeutic, diagnostic, prophylactic, or imaging molecules across polarized cells, and methods of their use. By associating two or more targeting elements in or with the composition, one of which binds to a first cell surface component, and another that binds to a second component of the cell that is not initially available to the composition in an amount sufficient to promote effective delivery of all or a portion of the composition into and/or across polarized cells, the compositions of the present invention can provide enhanced bioavailability of medically-relevant moieties.