发明名称 INHIBITORS OF AKT ACTIVITY
摘要 The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
申请公布号 WO2004041162(A3) 申请公布日期 2004.07.29
申请号 WO2003US34007 申请日期 2003.10.24
申请人 MERCK & CO., INC.;DUGGAN, MARK, E.;LINDSLEY, CRAIG, W.;ZHAO, ZHIJIAN 发明人 DUGGAN, MARK, E.;LINDSLEY, CRAIG, W.;ZHAO, ZHIJIAN
分类号 A61K31/495;A61K31/498;A61K45/06;C07D241/36;C07D487/02;C07D487/04;C07D495/04;C07D519/00 主分类号 A61K31/495
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