NITROANILINE-BASED ALKYLATING AGENTS AND THEIR USE AS PRODRUGS
摘要
<p>Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as produgs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjuction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.</p>
申请公布号
WO2004033415(A1)
申请公布日期
2004.04.22
申请号
WO2003NZ00225
申请日期
2003.10.08
申请人
AUCKLAND UNISERVICES LIMITED;DENNY, WILLIAM, ALEXANDER;ATWELL, GRAHAM, J.;YANG, SHANGJIN;WILSON, WILLIAM, ROBERT
发明人
DENNY, WILLIAM, ALEXANDER;ATWELL, GRAHAM, J.;YANG, SHANGJIN;WILSON, WILLIAM, ROBERT
