发明名称 |
Synthesis and separation of optically active isomers of erythromycin and their biological actions |
摘要 |
The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.
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申请公布号 |
US2004067898(A1) |
申请公布日期 |
2004.04.08 |
申请号 |
US20030432913 |
申请日期 |
2003.11.17 |
申请人 |
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发明人 |
SOMBERG JOHN;RANADE VASANT |
分类号 |
A61K31/7048;C07H17/08;(IPC1-7):C07H17/08;A61K31/704 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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