Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses

摘要

Compounds having activity against production of an inflammatory cytokine of formula (I)': A' is pyrrole; R<1'> is phenyl or naphthyl; R<2'> is pyridyl or pyrimidinyl; R<3'> is (IIa)', (IIb)' or (IIc)': m' is 1; E' is nitrogen; D' is >C(R<5'>)-, R<5'> is hydrogen, Substituent alpha' or Substituent beta'; B' is nitrogen-containing 5-membered heterocyclic; R<4'> is 1 to 3 substituents from Substituent alpha', Substituent beta' and Substituent gamma'; R<1'> and R<3'> are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R<2'>; Substituent alpha' is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or -NR<a'>R<b'>; R<a'> and R<b'> are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or R<a'> and R<b'> with the nitrogen atom form a heterocyclyl; Substituent beta' is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent gamma' is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.