NUCLEIC ACID CONSTRUCTS FOR THE DELIVERY OF POLYNUCLEOTIDES INTO DNA-CONTAINING ORGANELLES,AND USES THEREOF

摘要

A nucleic acid construct is provided. The nucleic acid construct includes: (a) a first polynucleotide segment including at least one nucleic acid sequence element; and (b) a second polynucleotide segment encoding a polypeptide including: (i) a nucleic acid binding domain being capable of specifically binding the at least one nucleic acid sequence element; and (ii) a localization signal for directing transport of the polypeptide into a DNA containing organelle, such that when the nucleic acid construct is introduced into a cell, expression of the polypeptide from the second polynucleotide segment directs transport of the nucleic acid construct into the DNA containing organelle.