发明名称 |
PHOSPHINIC PSEUDO-PEPTIDE DERIVATIVES FOR SELECTIVE INHIBITION OF THE ACTIVE C-TERMINAL SITE OF ANGIOTENSIN CONVERTING ENZYME (I) (ACE) |
摘要 |
The invention relates to the use of phosphinic pseudo-peptide derivatives for production of a medicament for the selective inhibition of the active C-terminal site of angiotensin converting enzyme (I). Said derivatives are of formula (II), where, R<sb>1</sb> = optionally a normal protective group for amino functions in peptide chemistry or an amino acid or a peptide protected by the above type of protective group, R<sb>2</sb> and R<sb>3</sb> = a natural or synthetic amino acid side chain and R<sb>4</sb> and R<sb>5</sb> = a hydrogen atom or a counter-ion. The above finds application in the prevention and treatment of cardiovascular disease in humans. |
申请公布号 |
WO03062247(A3) |
申请公布日期 |
2004.03.11 |
申请号 |
WO2003FR00129 |
申请日期 |
2003.01.16 |
申请人 |
COMMISSARIAT A L'ENERGIE ATOMIQUE;COTTON, JOEL;GEORGIADIS, DIMITRI;DIVE, VINCENT |
发明人 |
COTTON, JOEL;GEORGIADIS, DIMITRI;DIVE, VINCENT |
分类号 |
A61K31/662;A61P9/00;A61P9/08;A61P9/12;A61P43/00;C07F9/30;C07F9/32;C07F9/44;C07F9/572;C07K5/02 |
主分类号 |
A61K31/662 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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