Method of separating nucleoside phosphates

摘要

A nucleoside phosphate may be separated from a solution containing it using the ability of the nucleoside phosphate to intercalate into a layered double hydroxide. In particular, a first nucleoside phosphate may be separated from a second nucleoside phosphate by treating a solution containing the first and second nucleoside phosphates with a layered double hydroxide to preferentially intercalate the first nucleoside phosphate into the layered double hydroxide. The layered double hydroxide containing the intercalated nucleoside phosphate may be subsequently treated to recover the nucleoside phosphate. The methods disclosed provide useful procedures whereby nucleoside phosphates of enhanced purity may be obtained.