发明名称 |
BISPECIFIC ANTIBODIES THAT BIND TO VEGF RECEPTORS |
摘要 |
<p>The present invention is directed to production of antigen-binding proteins that bind specifically to an extracellular domains of two different VEGF receptors. The bispecific antigen-binding proteins block activation of the VEGF receptors and are used to reduce or inhibit VEGF-induced cellular functions such as mitogenesis of vascular endothelial cells and migration of leukemia cells. The antigen-binding proteins of the present invention can be monovalent or multivalent, have antigen-binding sites consisting of immunoglobulin heavy chain and light chain variable domains and may further include immunoglobulin constant domains.</p> |
申请公布号 |
WO2004003211(A1) |
申请公布日期 |
2004.01.08 |
申请号 |
WO2002US41372 |
申请日期 |
2002.12.24 |
申请人 |
IMCLONE SYSTEMS INCORPORATED;ZHU, ZHENPING |
发明人 |
ZHU, ZHENPING |
分类号 |
C07K16/28;(IPC1-7):C12P12/08;A61K39/395;C12P210/08 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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