发明名称 |
TRANSDERMAL DELIVERY RATE CONTROL USING AMORPHOUS PHARMACEUTICAL COMPOSITIONS |
摘要 |
A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent; and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (Cmax) to the average concentration (Cavg) for the physiologically active agent over the dosage interval within the range of 1 to 10. |
申请公布号 |
CA2489865(A1) |
申请公布日期 |
2003.12.31 |
申请号 |
CA20032489865 |
申请日期 |
2003.06.24 |
申请人 |
ACRUX DDS PTY LTD. |
发明人 |
REED, BARRY LEONARD;FINNIN, BARRIE CHARLES;WILKINS, NINA FRANCES;KLOSE, KATHRYN TRACI-JANE;MORGAN, TIMOTHY MATTHIAS |
分类号 |
A61K9/00;A61K9/12;A61K9/70 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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