摘要 |
The invention relates to a conjugate comprising an adiponectin polypeptide, and a first non-polypeptide moiety covalently attached to the adiponectin polypeptide, wherein the adiponectin polypeptide comprises an amino acid residue having an attachment group for said first non-polypeptide moiety, wherein said amino acid residue has been introduced in a position that in the parent adiponectin is occupied by a surface exposed amino acid residue. The non-polypeptide moiety may be a polymer, e.g. PEG. Further described is an isolated complex comprising an adiponectin trimer and calcium ions. The conjugate or complex is used in the treatment of disorders such as type 2 diabetes, cardiovascular disease and septic shock. |
申请人 |
MAXYGEN APS;MAXYGEN HOLDINGS LTD.;RASMUSSEN, POUL, BAAD;ANDERSEN, KIM, VILBOUR;PEDERSEN, ANDERS, HJELHOLT;SCHAMBYE, HANS, THALSGAARD;HALKIER, TORBEN;BOGSNES, ARE |
发明人 |
RASMUSSEN, POUL, BAAD;ANDERSEN, KIM, VILBOUR;PEDERSEN, ANDERS, HJELHOLT;SCHAMBYE, HANS, THALSGAARD;HALKIER, TORBEN;BOGSNES, ARE |