| 发明名称 |
SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION |
| 摘要 |
Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/ or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer~s Disease and Down~s syndrome are described.
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| 申请公布号 |
CA2486581(A1) |
申请公布日期 |
2003.12.18 |
| 申请号 |
CA20032486581 |
申请日期 |
2003.06.09 |
| 申请人 |
WYETH;ARQULE, INC. |
发明人 |
KREFT, ANTHONY FRANK;MANN, CHARLES WILLIAM;COLE, DEREK CECIL;MOORE, WILLIAM JAY;KUTTERER, KRISTINA MARTHA;KUBRAK, DENNIS MICHAEL;STOCK, JOSEPH RAYMOND;WOLLER, KEVIN ROGER;CASEBIER, DAVID SCOTT |
| 分类号 |
C07D307/14;A61K31/18;A61K31/335;A61K31/34;A61K31/341;A61K31/357;A61K31/4045;A61K31/4245;A61K31/655;A61P3/00;A61P25/28;A61P43/00;C07C311/17;C07C311/18;C07C311/19;C07C311/20;C07C311/29;C07C311/40;C07C323/49;C07D209/14;C07D209/16;C07D271/12;C07D307/52;C07D319/06;(IPC1-7):A61K31/18 |
主分类号 |
C07D307/14 |
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