| 摘要 |
The compound O-(2-[<18>F]fluoroethyl)-L-tyrosine has proven to be particularly suitable for positron emission tomography and has already been tested in clinical practice. Until now, the compound has been produced according to a relatively laborious method (Wester H.J. et al.; J. Nucl. Med. 1999; 40: 205-212). The invention relates to L-tyrosine derivatives of formula (1), wherein R<1> represents a suitable protective group for the carboxy group, R<2> represents a suitable protective group for the amino group, and R<3> represents a suitable leaving group. R<1> represents a methylthiomethyl group, a tetrahydrofuranyl group, a diphenylmethyl group, a para-methoxybenzyl group, a piperonyl group or a tert-butyl group, R<2> represents an alkyl group or an arylalkyl group, and R<3> represents a p-tosyloxy, methanesulfonyloxy, trifluoromethanesulfonyloxy or bromine. The invention also relates to a method for producing O-(2-[<18>F]-fluoroethyl)-L-tyrosine from the parent compounds of formula (1) and to a method for producing said parent compounds. |
