CRYSTAL FORMS AND MUTANTS OF RANK LIGAND

摘要

The present invention provides crystals of RANKL ectodomain complexes, detailed three dimensional structural information illustrating the interaction between RANKL and RANK and methods of utilizing the X-ray crystallographic data from such crystals and other structural data disclosed to design, identify and screen for compounds that modulate activity. The present invention also relates to machine readable media embedded with the three-dimensional atomic structure coordinates of RANKL crystalline complexes and subsets thereof, together with other structural data disclosed herein.