METHODS OF USING INTERLEUKIN-7 TO MODULATE PHYSIOLOGICAL PROCESSES IN MAMMALIAN PULMONARY FIBROBLASTS

摘要

The invention is based on the disclosure provided herein on the finding that the cytokine interleukin-7 (IL-7) limits the development of pulmonary fibrosis in clinically relevant models of idiopathic pulmonary fibrosis (IPF). As illustrated below, the disclosure provides additional information relating to the specific cellular mechanisms involved in this pathology and provides models for the assessment of different therapeutic modalities employing IL-7 as well as the assessment of new therapeutic agents and methods for the treatment of this syndrome.