QUINAZOLINE COMPOUNDS USEFUL IN THERAPY

摘要

Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1 represents C1-4 alkyl; R2 represents halo, C 1-4 alkyl, C 3-6 cycloalkyl, C3-6 cycloalkyloxy, -SO2(C1-4 alkyl), optionally substituted C1-4 alkyloxy, Het or -OHet; R3 represents a bicyclic group of the formula wherein X and Yare selected from C and N, provided that at least one is C; Ring A together with X and Y represents a 5- or 6-membered aromatic, ring containing 0, l, 2 or 3 nitrogen atoms in the ring; n is ), 1 or 2 L represents a direct link, C1-4 alkylene or C1-4 alkoxyalkylene; R4 represents H, -NR5R6, C3-6 cycloalkyl, -OR7, Het1 or Het4; R5 and R6 are independently selected from H, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4 alkylene, -SO2(C1-4 alkyl) and optionally substituted C1-4 alkyl. R7 is selected from H, C1-4 alkyl, C1-4 alkoxyalkyl, C3-6cycloalkyl, Het2 and C1-4alkyl-Het3; R8 is H or C1-4 alkyl; Het, Het1, Het2 and Het3 independently represent an optionally substituted 4 to 7 membered saturated heterocyclic group which may be mono- or bi-cyclic and which contains one or more heteroatoms selected from N, O or S; Het4 represents an optionally substituted 5 or 6 membered unsaturated heterocyclic group containing one or more heteroatoms selected from N, O or S; R9is H or C1-4 alkyl; R10 and R11 are independently selected from H and C1-4 alkyl; are useful in the treatment of hypertension, myocardial infarction, male erectile dysfunction (MED), hyperlipidaemia, cardiac arrhythmia, glaucoma and benign prostatic hyperplasia (BPH). They also find utility in the treatment of female sexual arousal dysfunction (FSAD).