发明名称 MODIFIED FACTOR VII
摘要 FIELD: medicine. SUBSTANCE: the present innovation deals with therapeutic methods to improve regional myocardial circulation during postischemic reperfusion, and, also, either prevent or minimize tissue lesions associated with postischemic perfusion. Indication mentioned is performed due to injecting composition containing pharmacologically acceptable Factor VII that has got , at least, one modification in his catalytic center which highly inhibits the capacity of modified Factor VII to activate plasmic Factor X or IX. EFFECT: higher efficiency of therapy. 18 cl, 11 dwg, 20 ex, 22 tbl
申请公布号 RU2211704(C2) 申请公布日期 2003.09.10
申请号 RU19990100089 申请日期 1997.06.06
申请人 NOVO NORDISK A/S;ZAJMODZHINETIKS INK. 发明人 PETERSEN LARS KRISTIAN;KHART CHARL'Z EH.;KHEDNER ULLA;RASMUSSEN MIRELLA EHSBAN
分类号 A61K38/55;A61K38/00;A61K38/16;A61K38/36;A61K38/43;A61K38/48;A61K38/49;C07K14/745;C12N9/64 主分类号 A61K38/55
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