发明名称 |
METHOD OF OBTAINING ESTROGENS FROM MARE'S URINE |
摘要 |
Recovery of a phenolics-depleted natural mixture of conjugated oestrogens from the urine of pregnant mares comprises (a) providing a liquid urine (which comprises a urine freed from mucous and solids, a concentrate of the latter or a urine retentate obtained by membrane filtration) and treating it with a water-soluble base to give a pH of at least 12 and subsequently treating with aqueous acid to adjust the pH to 5-8.5; (b) contacting the urine with a hydrophobised silica gel to adsorb the conjugated oestrogens and separating the gel from the mixture; (c) washing the gel with an aqueous buffer adjusted to pH 5-7; and (d) eluting the oestrogens from the gel using a mixture of water and a water-miscible solvent selected from ethers, lower alcohols and lower aliphatic ketones, and optionally concentrating the eluate; |
申请公布号 |
PL185920(B1) |
申请公布日期 |
2003.08.29 |
申请号 |
PL19960331885 |
申请日期 |
1996.08.30 |
申请人 |
SOLVAY PHARMACEUTICALS GMBH |
发明人 |
BAN IVAN;BORCHERS FRIEDRICH;HEINEMANN HENNING;RASCHE HEINZ-HELMER |
分类号 |
A61K31/56;A61K;A61K35/22;A61P5/30;A61P15/12;C07J75/00 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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