发明名称 |
Constructs for delivery of threrapeutic agents to neuronal cells |
摘要 |
A non-toxic polypeptide, for delivery of a therapeutic agent to a neuronal cell, comprises a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the translocation domain is not a HN domain of a clostridial toxin and is not a fragment or derivative of a HN domain of a clostridial toxin.
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申请公布号 |
US2003147895(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
US20020130973 |
申请日期 |
2002.06.25 |
申请人 |
SHONE CLIFFORD CHARLES;SUTTON JOHN MARK;SILMAN NIGEL |
发明人 |
SHONE CLIFFORD CHARLES;SUTTON JOHN MARK;SILMAN NIGEL |
分类号 |
A61K38/00;A61K48/00;C07K14/33;C12N9/02;C12N15/62;C12N15/87;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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