发明名称 |
Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals |
摘要 |
A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.
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申请公布号 |
US2003144798(A1) |
申请公布日期 |
2003.07.31 |
申请号 |
US20030338559 |
申请日期 |
2003.01.07 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GARDNER SHEA NICOLE |
分类号 |
G06F19/00;(IPC1-7):G06F19/00;G01N33/48;G01N33/50 |
主分类号 |
G06F19/00 |
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