RECOMBINANT BOVINE THROMBIN

摘要

Methods are disclosed for producing recombinant thrombin from precursor molecules that do not require activation by Factor Xa. The protein is produc ed from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. Metho ds for purification of the thrombin precursors are also described. Thrombin precursors produced from transformed or transfected host cells are auto- activated or secreted in an activated form.