| 摘要 |
1. A method, which comprises reacting 4'-chloro-4- biphenylcarboxaldehyde with sodium bisulfite to obtain the bisulfite adduct, being conducted in an aqueous/acetonitrile solution having an acetonitrile concentration sufficient to cause the bisulfite adduct to precipitate. 2. The method of Claim 1 wherein the ratio of acetonitrile to water is from about 2: 1 to about 13: 1. 3. A process for preparing 4'-chloro-4- biphenylcarboxaldehyde bisulfite adduct which comprises: (1) reacting 4'-chloro-4-biphenylcarboxaldehyde with sodium bisulfite in an aqueous/acetonitrile solution having an acetonitrile concentration sufficient to cause the bisulfite adduct to precipitate, (2) isolating the bisulfite adduct precipitate from the solution, (3) mixing the isolated bisulfite adduct in an aqueous/acetonitrile solution having a water concentration sufficient to cause the regenerated aldehyde to precipitate, and (4) converting the bisulfite adduct to 4'chloro-4-biphenylcarboxaldehyde. 4. The method of Claim 3 wherein the bisulfite adduct is isolated from the solution and mixed in an aqueous/acetonitrile solution having a water concentration sufficient to cause the regenerated aldehyde to precipitate. 5. The method of Claim 3 wherein the ratio of acetonitrile to water is from about 1: 3 to about 1: 5 acetonitrile to water. 6. The method of Claim 3 wherein the pH of the solution on step (3) is from about 12 to about 14. 7. The method of Claim 6 wherein the pH of the solution on step (3) is from about 10 to about 14. 8. A process for preparing 4'-chloro-4-biphenylcarboxaldehyde bisulfite adduct which comprises: (1) reacting 4'-chloro-4-biphenylcarboxaldehyde with sodium bisulfite in an aqueous/acetonitrile solution having an acetonitrile concentration sufficient to cause the bisulfite adduct to precipitate, (2) isolating the bisulfite adduct precipitate from the solution, (3) mixing the isolated bisulfite adduct in an aqueous/acetonitrile solution having a water concentration sufficient to cause the regenerated aldehyde to precipitate, and (4) converting the bisulfite adduct to 4'chloro-4-biphenylcarboxaldehyde. 9. The method of Claim 1 wherein the ratio of acetonitrile to water is from about 2:1 to about 13:1. 10. A compound of the formula:
|
