CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF
摘要
The present invention relates , inter alia to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compoun ds and their medical use. Also contemplated by the present invention are crysta ls of PDE5/PDE5 inhibitor complexes.
申请公布号
CA2478059(A1)
申请公布日期
2003.05.08
申请号
CA20022478059
申请日期
2002.10.24
申请人
PFIZER INC.
发明人
KAMP, SARAH HELEN;O'GARA, MARGARET MARY;RINGROSE, HEATHER JOAN;HOPKINS, ANDREW LEE;BROWN, DAVID GRAHAM;TAYLOR, WENDY ELAINE;ROBINSON, COLIN MARK;GROOM, COLIN ROGER;JENKINS, TIMOTHY MARK
