New aralkyl tetrahydropyridines useful as alpha tumor necrosis factor modulators, for the treatment of e.g. immunitory and inflammatory disorders, pain, Alzheimer's, Parkinson's, HIV and cancer

摘要

Aralkyl tetrahydropyridines (I), their salts, solvates, and N-oxides are new. Aralkyl tetrahydropyridines of formula (I), their salts, solvates, and N-oxides are new. X = N or CH; R1 = H, halogen, or CF3; n = 1 - 5; A = a group of formula (i), (ii), (iii), or (iv); m = 1 or 2. Independent claims are also included for: (1) the preparation of (I); and (2) an intermediate of formula (II). A<0> = a group of formula (i), (iii) or (iv).