| 摘要 |
The present invention is directed to methods for identifying compounds that modulate apoptosis, directly or indirectly, as measured by changes in expression of the bbc3 gene or a reporter gene, or by changes in the apoptot ic character of a cell. The present invention is also directed to methods for identifying compounds that modulate expression of the bbc3 gene and a method for identifying compounds that interact with a promoter of the bbc3 gene. Th e present invention is further directed to a method for modulating apoptosis i n a cell, a method for modulating bbc3 gene expression in a cell, a process fo r making a modulator of apoptosis, and a process for making a modulator of bbc 3 gene expression. Finally, the present invention is directed to compounds identified by each of the methods of this invention, and to promoters of the bbc3 gene and sequences homologous thereto.
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