BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF- DOLLAR G(A) CONVERTING ENZYME (TACE)

摘要

The present application describes to novel bicyclic hydroxamates derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, B<1>, B<2>, R<1>, and C are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF- alpha converting enzyme (TACE), aggrecanase, or a combination thereof.