PREPARATION OF OPTICALLY ACTIVE NORBORNYL AMINE DERIVATIVES

摘要

The present invention is directed to a process for preparing an optically active compound useful as an intermediate for the preparation of clinically important thromkbxane A2 (TXA2) receptor antagonist by resolving a racemic mixture of norbornyl amine of formula (I): (see formula I) wherin R1 is hydrogen, lower alkyl or lower alkyl substituted with -COOR3 at the terminal methyl residue; R3 is lower alkyl; Y is oxygen or methylene; m and n are independently 0 or 1 with a chiral acid.