| 发明名称 |
Branched hydrazone linkers |
| 摘要 |
Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.
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| 申请公布号 |
US6512101(B1) |
申请公布日期 |
2003.01.28 |
| 申请号 |
US19980136351 |
申请日期 |
1998.08.19 |
| 申请人 |
BRISTOL MYERS SQUIBB COMPANY |
发明人 |
KING DALTON;FIRESTONE RAYMOND A.;TRAIL PAMELA |
| 分类号 |
A61K31/00;A61K31/40;A61K31/401;A61K31/4015;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K39/395;A61K47/48;A61P31/00;A61P31/12;A61P35/00;A61P37/00;C07C281/02;C07D207/44;C07D207/452;C07H15/252;(IPC1-7):C07H17/02;C07H17/00;C07H15/04;C07H15/12 |
主分类号 |
A61K31/00 |
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