G-CSF CONJUGATES

摘要

Polypeptide conjugates with G-CSF activity comprising a polypeptide having a t least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a lowin vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils th an non-conjugates recombinant human G-CSF.