发明名称 |
HUMAN MINI-ANTIBODY CYTOTOXIC FOR TUMOR CELLS WHICH EXPRESS THE ERBB2 RECEPTOR |
摘要 |
The invention refers to a fully human miniantibody (scFv), called Erbicin, specific for the receptor ErbB2, with a phannacological, in particular antitumour, activity. It has been obtained from a larger fagmidic library (Griffin 1.) (19) of human synthetic scFv by panning (affinity selection on antigen) carried out on live cells that express various levels of ErbB2. The invention relates also to the DNA and amino acid sequences of said antibody, to the procedure for isolating it, to its use in therapy.
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申请公布号 |
CA2453435(A1) |
申请公布日期 |
2003.01.23 |
申请号 |
CA20022453435 |
申请日期 |
2002.07.10 |
申请人 |
UNIVERSITA' DEGLI STUDI DI NAPOLI "FEDERICO II" |
发明人 |
PALMER, DONALD BALFOUR;DE LORENZO, CLAUDIA;PICCOLI, RENATA;D'ALESSIO, GIUSEPPE;RITTER, MARY ALICE |
分类号 |
A61K31/7088;A61P35/00;C07K16/32;C12N1/21;C12N15/13;(IPC1-7):C12N15/13;A61K48/00;C07K19/00;C12N7/00;C12N7/01;C12P21/02;C12P21/08;C12N9/22;C07K16/28;A61K39/395;A61K38/46;C07K16/46;G01N33/53;G01N33/574;G01N33/577;C12N15/62;C12N15/63;C12Q1/68;C12N15/70;A61K31/708;A61K35/76 |
主分类号 |
A61K31/7088 |
代理机构 |
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