MUTATED CLASS II MAJOR HISTOCOMPATIBILITY PROTEINS

摘要

Provided are methods for directed mutagenesis and selection of MHC Class II proteins and single chain proteins with improved conformational stability and/or binding affinity for at least one cognate ligand. THe improved proteins are useful for identificaiton of T cells that are specific for the MHC Class II proteins and for treatment of disorders inlcuding autoimmune diseases, with the disorder determining the choice of the particular improved protein, peptide-protein complex or other ligand protein complex.