Recombinant anti-tumor RNASE

摘要

The invention relates to a cytotoxic reagent comprising a recombinant ribonuclease linked to an antibody directed against a cell surface of antigen on a cancerous B cell, wherein the recombinant ribonuclease has (a) measurable ribonuclease activity; (b) an amino terminal end beginning with a glutamine; (c) a leucine at position 11; an asparagine at position 21, a threonine at position 85, and a histidine at position 103, such positions being determined with reference to those specified amino acid positions of SEQ ID NO:2; and (d) substantial identity to SEQ ID NO: 2.