MEDICINE COMPOSITION

摘要

PROBLEM TO BE SOLVED: To obtain both an inhibitor capable of inhibiting a combination of HMG-I protein and presenilin-2mRNA exon 5, a neurocyte apoptosis inhibitor and a medicine composition useful for treating and preventing diseases caused by production of a presenilin-2mRNA exon 5-deficient splicing variant. SOLUTION: This inhibitor against a combination of HMG-I protein and a presenilin-2 gene comprises a compound for inhibiting a combination of HMG-I protein and presenilin-2mRNA exon 5. This neurocyte apoptosis inhibitor comprises the inhibitor. This medicine composition comprises the inhibitor or the neurocyte apoptosis inhibitor. The inhibitor or the neurocyte apoptosis inhibitor is used for producing a medicine for treating or preventing brain disorders caused by production of a presenilin-2mRNA exon 5-deficient splicing variant.