| 摘要 |
It is intended to provide a novel transgenic animal wherein .gamma.- aminobutyric acid neurons can be visualized in vivo; a method of constructin g the same; and a novel model animal of palatoschisis. A transgenic animal wherein a green fluorescent protein gene is inserted into the same reading frame as an exon of a glutamate decarboxylase gene, and a model animal of palatoschisis comprising the above transgenic animal. In the transgenic animal, the fluorescence of the knockin fluorescent gene at the expression site of the glutamate decarboxylase can be observed and thus the expression site of the gene in vivo can be identified. Moreover, it is useable as a mod el animal of palatoschisis in treating palatoschisis.
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