| 摘要 |
PROBLEM TO BE SOLVED: To provide a transgenic nonhuman mammal which is usable as a disease model animal for preventives or remedies for chondrogenic failure, osteogenetic failure, osteoporosis, arthritis deformans, chronic rheumatoid arthritis, arthritis, synovitis, metabolic arthritis, eye diseases, malignant tumor and complications thereof and, therefore, makes it possible to clarify the pathological mechanisms of these diseases, examine methods for treating these diseases and screen remedies therefor. SOLUTION: The nonhuman mammal in which MMP-19 gene is transferred is created. |
