发明名称 |
COMPOSITIONS AND METHODS FOR REGULATING BACTERIAL PATHOGENESIS |
摘要 |
This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
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申请公布号 |
WO0032152(A3) |
申请公布日期 |
2002.12.12 |
申请号 |
WO1999US28751 |
申请日期 |
1999.12.02 |
申请人 |
PRINCETON UNIVERSITY;BASSLER, BONNIE;SURETTE, MICHAEL, G. |
发明人 |
BASSLER, BONNIE;SURETTE, MICHAEL, G. |
分类号 |
G01N33/50;A61K31/00;A61K38/00;A61K45/00;A61P31/04;A61P43/00;C07C49/17;C07K14/00;C07K14/28;C12N1/20;C12N5/02;C12N15/09;C12P7/26;C12Q1/02;C12Q1/68;C12R1/63;G01N21/76;G01N21/77;G01N21/78;G01N33/15;G01N33/53;G01N33/566;G01N33/577;(IPC1-7):A61K39/106;C12N5/00;G01N33/569 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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