SERINE PROTEASE INHIBITORS COMPRISING A HYDROGEN-BOND ACCEPTOR

摘要

Compounds, useful as protease inhibitors, of the formula (I): where: Ar is a ring or ring system, for example a benzene ring, and may be substituted by one or more moieties in addition to X and LJ; X is a functional group which is a hydrogen-bond acceptor, e.g. a nitro or boronate group BY<1>Y<2>; L is a linker, most preferably (CR<5>R<6>)-S-; J is a moiety containing a basic nitrogen atom but not containing an amino acid residue, preferably amidino, guanidino, amino, carboxamido, hydroxylamino, or imidazolyl, or an N-substituted analogue thereof.