| 摘要 |
<p>N,N-disubstituted amines in which the amino nitrogen atom is bound to the carbon of an aromatic ring disubstituted in the positions ortho to the carbon atom, are prepared by allowing a primary amine and a compound in which an ortho, ortho-disubstituted aromatic compound carrying a nucleofuge substituent, to react in a basic environment in the presence of a catalytic palladium(0) or nickel complex and a ligand, the ratio of palladium(0) or nickel complex to ligand being greater than at least 1:1. A typical embodiment involves the reaction of 2-methyl-6- ethylphenyl-trifluoromethylsulfonate and (S)-1-methoxy-2- aminopropane in the presence of bis(dibenzylideneacetone)palladium, tri-tert.- butylphosphine, and sodium tert.-butoxide to yield (S)-N-(1- methoxyprop-2-yl)-2-methyl-6-ethylphenylamine.</p> |
