发明名称 |
N-ACETYLCYSTEINE COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF DRUG TOXICITY |
摘要 |
The invention provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N-acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent. The invention also provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N-acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent whose side effects are made worse by increased oxidative stress or treatment related decreases in subject cysteine/glutathione levels or are otherwise relieved by administration of NAC. |
申请公布号 |
WO02078627(A2) |
申请公布日期 |
2002.10.10 |
申请号 |
WO2002US09442 |
申请日期 |
2002.03.28 |
申请人 |
BIOADVANTEX PHARMA INC. |
发明人 |
HERZENBERG, LEONARD, A.;DE ROSA, STEPHEN, C.;ANDRUS, JAMES;HERZENBERG, LEONORE A. |
分类号 |
A61K31/277;A61K31/167;A61K31/198;A61K31/223;A61K31/7072;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P39/00;A61P39/02;A61P43/00 |
主分类号 |
A61K31/277 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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