发明名称 |
5-cyano-2-aminopyrimidine derivatives |
摘要 |
Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R1 is a hydrogen atom or a straight or branched chain alkyl group; R2 is a -X1-R3 group where X1 is a direct bond or a linker atom or group, and R3 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states associated with angiogenesis.
|
申请公布号 |
US2002147339(A1) |
申请公布日期 |
2002.10.10 |
申请号 |
US20020151518 |
申请日期 |
2002.05.20 |
申请人 |
BATCHELOR MARK JAMES;MOFFAT DAVID FESTUS CHARLES;DAVIS JEREMY MARTIN;HUTCHINGS MARTIN CLIVE |
发明人 |
BATCHELOR MARK JAMES;MOFFAT DAVID FESTUS CHARLES;DAVIS JEREMY MARTIN;HUTCHINGS MARTIN CLIVE |
分类号 |
A61K31/505;A61K31/506;A61P9/10;A61P9/14;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P43/00;C07D239/42;C07D401/04;C07D401/14;C07D403/12;C07D409/04;(IPC1-7):C0743/02;C0749/02 |
主分类号 |
A61K31/505 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|