发明名称 |
PROCESS FOR PRODUCING BICYCLOCARBOXYLIC ACID DERIVATIVE |
摘要 |
<p>A process for producing a 2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylic acid derivative represented by the formula (I) (wherein R<1> represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyl substituted by C3-6 cycloalkyl, C1-6 alkyl substituted by optionally substituted phenyl, C1-6 alkyl substituted by C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 alkyl substituted by C1-6 alkylthio, C1-6 mercaptoalkyl, or optionally substituted phenyl), characterized by reacting a 4-hydroxy-2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivative represented by the formula (II) (wherein R<1> is the same as defined above; and R<2> represents hydrogen or a hydroxyl-protecting group) in the presence of an acid or base. Also provided is a process for producing a compound useful in the efficient synthesis of a 2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative.</p> |
申请公布号 |
WO02072525(A1) |
申请公布日期 |
2002.09.19 |
申请号 |
WO2002JP02254 |
申请日期 |
2002.03.11 |
申请人 |
TAISHO PHARMACEUTICAL CO.,LTD.;NAKAZATO, ATSURO;KUMAGAI, TOSHIHITO;SAKAGAMI, KAZUNARI |
发明人 |
NAKAZATO, ATSURO;KUMAGAI, TOSHIHITO;SAKAGAMI, KAZUNARI |
分类号 |
C07C51/377;C07C67/327;(IPC1-7):C07C51/377;C07C62/24;C07C69/757 |
主分类号 |
C07C51/377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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