发明名称 |
Method of transplantation using chemotherapy-treated allogeneic cells that enhance immune responses without graft versus host disease |
摘要 |
The present invention provides a method of transplanting hematopoietic cells between genetically unrelated individuals, comprising administering to the recipient, in combination with the administration of the hematopoietic cells, an amount of mononuclear cells which are treated so as to substantially reduce their ability to cause graft versus host disease while they retain their ability to proliferate in the recipient. The treated mononuclear cells can facilitate engraftment of hematopoietic cells when transplanted in combination with hematopoietic cells, treat or prevent infections, and treat cancer. |
申请公布号 |
US2002127208(A1) |
申请公布日期 |
2002.09.12 |
申请号 |
US20010945339 |
申请日期 |
2001.08.31 |
申请人 |
WALLER EDMUND K.;HILLYER CHRISTOPHER D.;ROBACK JOHN |
发明人 |
WALLER EDMUND K.;HILLYER CHRISTOPHER D.;ROBACK JOHN |
分类号 |
A61K35/12;A61K35/14;A61K39/00;A61P31/12;A61P35/00;A61P37/02;C12N5/071;C12N5/0783;(IPC1-7):A61K48/00;A61K31/522;A61K31/711 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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