NOVEL GLUTAMATE RECEPTOR MODULATORY PROTEINS AND NUCLEIC ACID MOLECULES AND USES THEREFOR

摘要

Novel mGluR5M polypeptides, proteins, and nucleic acid molecules are disclosed. In additions to isolated, full-length mGluR5M proteins, the invention further provides isolated mGluR5M fusion proteins, antigenic peptides and anti-mGluR5M antibodies. The invent ion also provides mGluR5M nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a mGluR5M gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.