发明名称 |
NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES AGAINST HIV-1, THEIR PRODUCTION AND USES |
摘要 |
The present invention relates to a novel human antibody, and antigen-binding portion thereof, that specifically binds HIV-1 gp120 protein and that has HI V- 1- neutralizing activity. The present invention also relates to a cell line that produces an antibody of this invention. The present invention further relates to a pharmaceutical composition or a kit comprising an antibody or antigen binding portion thereof of this invention. The present invention further relates to a method of using the antibody of this invention to treat a subject with an HIV-1 infection or prevent a subject from getting an HIV-1 infection. The present invention also relates to a novel method of making an antibody of this invention. The method involves using a non-human transgenic animal. The present invention further relates to methods of identifying regions of gp120 for use as HIV-1 vaccine.
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申请公布号 |
CA2436091(A1) |
申请公布日期 |
2002.08.01 |
申请号 |
CA20022436091 |
申请日期 |
2002.01.25 |
申请人 |
ABGENIX, INC.;PUBLIC HEALTH RESEARCH INSTITUTE |
发明人 |
CORVALAN, JOSE R.;HE, YUXIAN;PINTER, ABRAHAM |
分类号 |
A01K67/027;A61K39/395;A61K45/00;A61P31/12;A61P31/18;A61P37/02;A61P37/04;C07K16/08;C07K16/10;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/24;C12N15/09;C12N15/13;C12N15/85;C12P21/08;C12Q1/70;G01N33/15;G01N33/50;G01N33/566;(IPC1-7):C07K16/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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地址 |
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