| 摘要 |
The invention relates to compounds of formula (I), wherein the variables have the following meanings: D means a phenyl or a pyridyl which is unsubstituted or is mono- or polysubstituted by Hal, A, OR<2>, N(R<2>)2, NO2, CN, COOR2 or CON(R<2>)2; R<1> means H, Ar, Het, cycloalkyl or A, which can be substituted by OR<2>, SR<2>, N(R<2>)2, Ar, Het, cycloalkyl, CN, COOR<2> or CON(R<2>)2; R<2> means H or A, E means phenylene which can be mono- or polysubstituted by Hal, A, OR<2>, N(R<2>)2, NO2, CN, COOR<2> or CON(R<2>)2 or piperidin-1,4-diyl, W means AR, Het or N(R<2>)2 and if E=piperidin-1,4-diyl, also R2 or cycloalkyl; and X means NH or O. These compounds are inhibitors of the coagulation factor Xa and can be used for the prevention and/or therapy of thromboembolic diseases and for treating tumours.
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