发明名称 |
Acellular pertussis vaccines and methods of preparation thereof |
摘要 |
Acellular pertussis vaccines comprise purified toxin or toxoid thereof, filamentous haemagglutinin, pertactin and fimbrial agglutinogens formulated to confer protection to at least 70% of members of an at-risk population. The fimbrial agglutinogens may be prepared from a Bordetella strain, particularly a B. pertussis strain, by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material. |
申请公布号 |
US6399076(B2) |
申请公布日期 |
2002.06.04 |
申请号 |
US19980945750 |
申请日期 |
1998.06.09 |
申请人 |
AVENTIS PASTEUR LIMITED |
发明人 |
VOSE JOHN R.;FAHIM RAAFAT E. F.;JACKSON GAIL E. D.;TAN LARRY U. L.;HERBERT ANDREW;BOUX LESLIE;BARRETO LUIS;THIPPHAWONG JOHN;KLEIN MICHEL H. |
分类号 |
A61K39/00;A61K39/10;A61K39/116;A61K39/155;A61P31/04;A61P37/00;C07K14/235;(IPC1-7):A61K39/10;A61K39/02;A61K39/38 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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